The effects of muscle relaxants (vecuronium, pancuronium, d-tubocurarine, and succinylcholine) for endotracheal intubation on intraocular pressure, blood pressure, heart rate, and arrhythmia were studied in 60 patients undergoing general anesthesia,
The patients were divided into 4 groups : vecuronium group (0.1 mg/kg), pancuronium group (0.08 mg/kg), d-tubocurarine group(0.4 mg/kg), and succinylcholine group(1 mg/kg) according to be administrated.
Before induction of anesthesia, initial measurement of intraocular pressure(control value) was taken with Schiotz tonometer after instilling of a 0.5% pontocaine on conjunctival sac. Subsequent measurement were undertaken as soon as the lid reflex was lost after thiopental sodium injection and then at 75-100% depression of first twitch height of train-of-four after intravenous administration of muscle relaxants. It was measured at 1, 3, 5, 10 minutes after endotracheal intubation too. Blood pressure(systolic and diastolic), heart rate, and ECG atnormalities were observed in all cases.
The results were as follows;
1, After thiopental sodium injection, intraocular pressure(IOP) decreased than the control value.
2. At 70-100% depression of first twitch height, IOP decreased significantly in vecuronium, pancuronium and d-tubocurarine group, but increased significantly in succinylcholine group than the control value.
3. After 1 minute of endotracheal intubation, IOP increased in all groups. There was no stastistical significance in vecuronium group compared with the control value.
4. After 3 minutes of endotracheal intubation, IOP decreased in all groups.
5. The changes of systolic and diastolic blood pressure and heart rate in vecuronium group were the smallest value among all groups.
6. There was no arrythmia in vecurouium group.
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